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Pharmacology: Pharmacodynamics: Pharmacological actions: BELCID FORTE has an action of antacid, antiflatulence.
BELCID FORTE acts by neutralizing the gastric acid and also has antifoaming action.
Mechanism of actions: The clinical use of antacids is based on their ability to increase the pH of gastric secretions: Aluminium hydroxide or oxide reacts with hydrochloric acid to form aluminium chloride and water.
Magnesium hydroxide rapidly reacts with hydrochloric acid to form magnesium chloride and water.
Simethicone acts by coagulating the mucus-surrounded gas bubbles in the GI tract and expelling them.
Pharmacokinetics: Aluminium hydroxide or oxide is slowly solubilized in the stomach after neutralizing hydrochloric acid to form aluminium chloride, about 17 - 30% of the aluminium chloride is absorbed and is rapidly excreted by the kidney in patients with normal renal function.
Magnesium hydroxide neutralizes hydrochloric acid in the stomach to form magnesium chloride and about 15 - 30% of the magnesium chloride is absorbed and is rapidly excreted by the kidney in patients with normal renal function.
Simethicone is not absorbed from GI tract and is excreted unchanged in feces.
